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title

CONCISE REVIEW ON MODIFIED RELEASE DRUG PRODUCTS OF MATRIX TABLETS AS DRUG DELIVERY SYSTEM

Author(s):

B.Keerthana

Keywords:

drug delivery system,oral route, sustained release, matrix system, polymer.

Abstract

Oral route of drug delivery is the most preferred method among the available routes of drug administration. However, the traditional conventional or immediate oral dosage form especially tablets, capsules have a few drawbacks such as rapid rate of drug absorption and onset of accompanying pharmacodynamics effects results in rapid loss in the desired therapeutic activity or poor patient compliance that could be fixed and altered by using current modified release drug products. A regulated and sustained drug delivery system prolongs the duration of action by slowing the drug's release rate and assisting in maintaining a consistent plasma drug concentration, which eliminates poor patient compliance, repeated dosages, and see-saw oscillations after administration into the body. In that matrix tablets, a crucial tool among the numerous formulation options of modified release tablets. A number of hydrophilic or hydrophobic polymers can be used to make matrix tablets using either the direct compression or the wet granulation technique. Rate and extent are the main factor that controls how quickly drugs are released from the matrix tablets. The primary goal of this review is to provide comprehensive understanding of modified release drug product of matrix tablets and its benefits, criteria for drug selection and its formulations details.

Other Details

Paper ID: IJSARTV
Published in: Volume : 9, Issue : 4
Publication Date: 4/1/2023

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