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Volume 5 Issue 3

March 2019

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title

A COMPARATIVE STUDY OF THE ANTIBACTERIAL AND SHORT TERM IN VITRO CYTOTOXICITY STUDIES OF THE COPPER(II) COMPLEXES OF A TRIDENTATE N,N,S DONOR LIGAND(HBPSTC) DERIVED FROM 2-BENZOYLPYRIDINE AND PIPERAZINE BASE.

Author(s):

Janey Mary Mathew

Keywords:

Thiosemicarbazone, 2-Benzoylpyridine, Copper (II) complexes, EPR,,antimicrobial.

Abstract

Five copper(II) complexes of the N, N, S-donor ligand Hbpstc were synthesised by refluxing equimolar amounts of the ligand and the copper(II) metal salts in methanol. The ligand ,Hbptsc was prepared by the reported procedure of Scovill et al. Both the ligand as well as the complexes were characterized by elemental CHN analysis. Molar conductivity studies of the complexes in 10-3M solutions in DMF at room temperature showed that the complexes were non electrolytes with the stoichiometry of the type [CuLX] where X= Cl(1), NO3(2), SO4 (3), N3(4), SCN(5) confirmed by very low molar conductance values. The complexes were tested for their antimicrobial activities using streptomycin as positive control against gram positive and Gramnegative bacteria. The short term in vitro cytotoxiivty studies. Studies of the copper (II) complexes were done following trypan blue dye exclusion method against the Dalton’s Lymphoma Ascites tumour cells extruded from the peritoneal cavity of mice.

Other Details

Paper ID: IJSARTV
Published in: Volume : 5, Issue : 3
Publication Date: 3/1/2019

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