CONTROL OF BURN WOUND PATHOGENS BY ANTIBACTERIAL COMPOUNDS ISOLATED FROM BACILLUS THURINGIENSIS

Bacillus thuringiensisis commonly known for its larvicidal activity is being widely used in controlling disease vector insects. Besides its environmental use Bacillus thuringiensis also produce proteinic compounds such as bacteriocin and chitinolytic enzymes which are responsible for antibacterial activity against human pathogens. Bacillus thuringiensis isolated from soils collected from different areas of Thane district showed antibacterial activity against the clinical pathogens isolated from Burn wound samples procured from local hospitals. Pathogenic bacteria isolated from burn samples were also tested for its antibiotic susceptibility with 16 different broad spectrum antibiotics. Bacillus thringiensis inhibiting maximum clinical pathogens were selected and subject to solvent extraction process, which yielded out the antibacterial compound. This compound was dissolved in DMSO and further used for determining its minimum inhibitory concentration. Organisms than are inhibited by Bacillus thuringiensis belong to thefollowing genus, Pseudomonas, Staphylococcus, Bacillus and Proteus