BIOLOGICAL SCREENING OF SOME NEWLY SYNTHESIZED N-PHENYL-4-ARYL-POLYHYDROQUINOLINES

In this paper we are discussing about the biological activity of newly synthesized substituted quinoline compounds was evaluated by agar well diffusion method. Quinolines are having most potent biological activity like, here N-phenyl-4-aryl-polyhydroquinolines. All the twelve synthesized target compounds (4a-4l) were assayed for their in vitro antimicrobial activity against S. aureus and B. subtilis representing Gram-positive bacteria, E. coli and P. fluorescens representing Gram-negative bacteria, and S. cerevisiae and C. albicans representing fungal yeasts by agar well diffusion method using ciprofloxacin against bacteria and fluconazole against fungi as the reference drugs. The results were recorded for each tested compound as the average diameter of inhibition zones of microbial growth surrounding the well in mm.The minimum inhibitory concentration (MIC) shown in Table 4.1 &4.2.